Action of formamidine pesticides on octopamine receptors. The pesticidal and pestistatic properties of the formamidines may result from actions on octopaminergic systems. This chapter provides a brief guide to the mode of action of the antiparasitic compounds in current use. The actions of a range of formamidines have been investigated biochemically and physiologically on octopamine receptors in the locust schistocerca gregaria. When these insecticide classes are examined, it becomes clear that the majority of insecticides in use today exert their toxic action on the insect nervous system. In stimulation experiments its responded to octopamine leading to an inhibition of. Robert hollingworth michigan state university, mi msu. The action of formamidines on octopamine receptors in the. Cloning of biogenic amine receptors from moths bombyx mori and. Mode of action of agents used against arthropod parasites. We report here that the formamidine acaricideinsecticide, chlordimeform cdm, and its demethylated derivative can mimic the actions of octopamine at the locust neuromuscular junction.
Unfortunately, this book cant be printed from the openbook. Actions of sympathomimetic amines on the isolated light organ of the firefly photinus pyralis. Formamidine pesticidesactions in insects and acarines. The formamidine pesticide chlordimeform and its ndemethylated metabolites cause the light organ of the firefly photinus pyralis l. Synergistic actions of formamidine insecticides on the activity of pyrethroids and neonicotinoids against aedes aegypti diptera. Plant essential oils and formamidines as insecticides acaricides. Action of formamidine pesticides on the octopamine. Table of contents april 04, 1980, 208 4439 science. The formamidines are a novel group of acaricideinsecticides, unique both in chemical structure and in their range of biological activities. A similar effect of locomotor activity on temporal tuning functions was reported for. Octopaminergic modulation of temporal frequency tuning.
The results are similar to those from the firefly light organ with phentolamine blocking the action of dcdm, cdm and octopamine. Hollingworthoctopaminelike actions of formamidines in the firefly light organ. We report here that the formamidine acaricide insecticide, chlordimeform cdm, and its demethylated deivative can mimic the actions of octopamine at the locust neuromuscular junctions. Synergistic actions of formamidine insecticides on the activity of. Octopamine immunoreactivity in the fruit fly drosophila. Abstract the formamidine pesticide chlordimeform and its ndemethylated metabolites cause the light organ of the firefly photinus pyralis l. Toxicity, interactions, and metabolism of formamidine. It stimulates activity of the firefly light organ nathanson, 1979, induces flight motor activity, and acts as neurotransmittermodulator in the locust central nervous system cns. The action of formamidines on octopamine receptors in the locust. All the formamidines tested chlordimeform cdm, demethylchlordimeform dcdm, amitraz, and uk 16353 mimicked the action of octopamine by 1 increasing the amplitude and relaxation rate of slow motorneurone tension in the extensortibiae. If you need to print pages from this book, we recommend downloading it as a pdf. Plant essential oils and formamidines as insecticidesacaricides.
Theformamidinepesticide chlordimeform andits ndemethylatedmetabolites cause the light organ ofthefirefly photinus pyralis l. Pharmacological characterization of a bombyx mori alphaadrenergiclike octopamine receptor stably expressed in a mammalian cell line. Ethological and experimental approaches to behavior analysis jstor. The emphasis reflects more the chemical usage than the extent of the literature. This gives the clearest evidence to date of the site of action of the formamidines and indicates a novel mode of action for these pesticides. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Environmental protection agency, and approved for publication. Monodemethyl chlordimeform is active at doses as low as 5 nanograms per insect when applied topically. Nervous systems in invertebrates pp 573602 cite as. Alpha2adrenoceptors as a target for formamidine pesticides. The formamidine pesticide chlordimeform and its n demethylated metabolites cause. Receptor in hek293 cells and action of a formamidine insecticide. No general agreement exists concerning their mechanisms of action. In a number of model systems, including the firefly light organ 4 and the locust extensortibiae muscle 5, the formamidines have been shown to activate octopamine receptors.
The action of two formamidines, chlordimeform cdm and desmethylchlordimeform dcdm, on isolated fat body of locusts has been examined. This new digital representation of the original work has been recomposed from xml files created from the original paper book, not from the original typesetting files. Chemical strategies for resistance management pesticide. Monoamines as targets for insecticide discovery springerlink. Introduction the formamidines are an important class of pesticides which are used to control a variety of insect species and ticks. In view of the current interest in octopamine and its receptors and the demonstration that octopamine receptors are at least one site of action of formamidines, we have examined the action of two formamidines chlordimeform cdm and desmethylchlordimeform dcdm on the octopamine receptors on locust fat body. Scientific literature fireflyers international network. Hollingworth rm, murdock ll 1980 formamidine pesticides.